Background: Patients could develop endocrine and exocrine pancreatic insufficiency after acute pancreatitis (AP),\nbut the morbidity, risk factors and outcome remain unclear. The aim of the present study was to evaluate the\nincidence of endocrine and exocrine pancreatic insufficiency after AP and the risk factors of endocrine pancreatic\ninsufficiency through a long-term follow-up investigation.\nMethods: Follow-up assessment of the endocrine and exocrine function was conducted for the discharged patients\nwith AP episodes. Oral Glucose Tolerance Test (OGTT) and faecal elastase-1(FE-1) test were used as primary parameters.\nFasting blood-glucose (FBG), fasting insulin (FINS), glycosylated hemoglobin HBA1c, 2-h postprandial blood glucose\n(2hPG), Homa beta cell function index (HOMA-�²), homeostasis model assessment of insulin resistance (HOMA-IR) and\nFE-1 were collected. Abdominal contrast-enhanced computed tomography (CECT) was performed to investigate the\npancreatic morphology and the other related data during hospitalization was also collected.\nResults: One hundred thirteen patients were included in this study and 34 of whom (30.1%) developed diabetes\nmellitus (DM), 33 (29.2%) suffered impaired glucose tolerance (IGT). Moreover, 33 patients (29.2%) developed mild to\nmoderate exocrine pancreatic insufficiency with 100�¼g/g50%, WON and insulin resistance were the independent risk factors of\nnew onset diabetes after AP.
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